The greatness of Science comes from the capacity of scientist to questions their own work, and to change their theories when flaws are pointed out.

Not sure if we were successful on this one, i will let you judge by yourself.

Commentary by George et al.

Negative reinforcement via motivational withdrawal is the driving force behind the transition to addiction.

George O, Koob GF, Vendruscolo LF. link to PDF

Original Review:

A multistep general theory of transition to addiction.

Piazza PV, Deroche-Gamonet V. link to PDF

Reply from Piazza and Deroche-Gamonet:

A general theory of transition to addiction it was and a general theory of transition to addiction it is : Reply to the commentaries of Ahmed, Badiani, George & Koob, Kalivas & Gipson, and Tiffany.

Piazza PV, Deroche-Gamonet V. Link to PDF